Immunity

from v1.4 host immunity was added to the model. host immunity has been added in a simple SEIR approach to the original model, using a scheme that closely follows [#!laneri:10!#]. In the default immunity scheme, immunity is gained as a result of infectious bites, with an e-folding scale set such that 95% of individuals receiving 100 infectious bites per year (EIRa=100) will be clinically immune [#!filipe:07!#,#!doolan:09!#]. A Newtonian relaxation loss term is applied so that 95% of individuals lose immunity after 3 years. In addition to clinical immunity, the model also accounts for transmission blocking immunity in the same way as [#!klein:08!#,#!laneri:10!#], by reducing the host to vector transmission probability in immune individuals [#!boudin:05!#], (and see review in supplementary tables 5 and 7 in [#!ermert:11a!#]).


Table: immunity and transmission parameters
parameter definition default units
rhostclear clearance rate for non-immune adults 150 days
rpthost2vect probability of infected transmission from infected host to vector 0.2  
rptvect2host probability of infected transmission from infected vector to host 0.3  
rimmune_gain_eira Annual EIR required to gain full immunity 100 bites pppd
rimmune_loss_tau E-folding timescale for immunity loss 365 days
rpop_death_rate dead and replacement rate 0.02 fraction per year
rpopdensity_min minimum population density for code to run 5e.-7 per km$^{-2}$
rbitehighrisk ratio of rate of bites for high risk (E) to low risk (S) categories 5