Summary. Internal radiation dosimetry estimations are essential to evaluate the safety and efficacy of radioimmunoconjugates during the radioimmunotherapy of cancer. A methodology for three-dimensional doses calculations has been developed, based on the MIRD formalism at voxel level. It includes processing and quantitative analysis of SPECT images, 3D doses assessments and a dose report package based on image segmentation. Our proposal has been focused on the dose estimations of patients bearing brain tumours who are treated with locoregional radioinmunotherapy techniques using the 188Re labeled humanized monoclonal antibody h-R3. The methodology developed and the preliminary clinical results are going to be presented in the Seminar.

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(*) Dr Leonel Alberto Torres Aroche is a researcher of the Centre for Clinical Researchin Havana, Cuba. His B.Sc. in nuclear physics was from the High Institute of Nuclear Sciences and Technologies in Havana in 1991 and his M.Sc. in Nuclear Physics was specifically in medical physics. It was obtained at the same institute in 1998. In 2002 he was awarded the Junior Associateship of the ICTP.

He was the coordinator of local project for the implementation of a national program for quality control of nuclear medicine instruments and has collaborated with the development of a national program for quality control. More recently he has developed a methodology for 3-dimensional internal radiation dosimetry calculations.

Dr. Torres Aroche has numerous recent publications in national and international journals related with his work. He has participated in several national research projects related to methodological aspects of internal radiation dosimetry, biodistribution and pharmacokinetics studies, as well as in clinical researches to evaluate the radiation safety of gamma and beta emitter labelled monoclonal antibodies for diagnosis and therapy of malignant diseases.

He has been involved in the organization and development of regional and coordinated research projects supported by the International Atomic Energy Agency. He has participated as professor in pre and post-graduated courses in national and international educational activities; he has also supervised bachelor and Master thesis of several medical physics students.